Dose-intensified Image-guided Fractionated Stereotactic Body Radiation Therapy for Painful Spinal Metastases (DOSIS) versus Conventional Radiation Therapy: a Phase II Randomised Controlled Trial


Prof. Dr. Matthias Guckenberger
University Hospital Zurich

Study design:

● Phase II, international, multicenter, randomized, open-label, prospective, controlled study

Study objective:

● To compare long-term pain control after dose-intensified image-guided hypofractionated SBRT employing SIB versus conventional radiation therapy for painful mass-type spinal metastases.

Project status:

  •  Study closed (219 patients recruited)
  • Follow-up ongoing

Major findings and results:

Matthias Guckenberger, Maria Hawkins, Michael Flentje, Reinhart A Sweeney
Fractionated radiosurgery for painful spinal metastases: DOSIS - a phase II trial.
BMC Cancer 2012 Nov 19;12:530. doi: 10.1186/1471-2407-12-530.