AURORA trial : A Multicenter Analysis of Stereotactic Radiotherapy to the Resection Cavity of Brain Metastases
Study PI:
PD Dr. Denise Bernhardt (Part 1)
Technical University of Munich (TUM)
denise.bernhardt@mri.tum
PD Dr. Jan Peeken (Part 2)
Technical University of Munich (TUM)
jan.peeken@tum.de
Prof. Dr. med. Stephanie E. Combs
Technical University of Munich (TUM)
stephanie.combs@tum.de
Study design:
● Multi-center, international retrospective study
Study objective:
● Part 1: clinical evaluations regarding prognosis, fractionation, toxicity, OS, PFS, surgery, GPA, RPA scoring
● Part 2: radiomics and deep learning analysis for metastases characterizration, prognostic assessment and segmentation.
Project status:
● Data collection and transfer completed at all centers
● Statistical analysis ongoing (Part 1)
● Development of radiomics and deep learning models ongoing (Paart 2)
GitHub:
● MRI-based UNet segmentation model for brain metastases: http://github.com/neuronflow/AURORA