{"id":828,"date":"2022-08-31T10:45:28","date_gmt":"2022-08-31T08:45:28","guid":{"rendered":"https:\/\/www.degro.org\/ag-stereotaxie\/?page_id=828"},"modified":"2025-02-11T12:21:54","modified_gmt":"2025-02-11T11:21:54","slug":"preop-2-trial","status":"publish","type":"page","link":"https:\/\/www.degro.org\/ag-stereotaxie\/preop-2-trial\/","title":{"rendered":"PREOP-2 Trial"},"content":{"rendered":"<div id=\"pl-828\"><style scoped>#pg-828-0 .panel-grid-cell { float:none } #pl-828 .panel-grid-cell .so-panel { margin-bottom:30px } #pl-828 .panel-grid-cell .so-panel:last-child { margin-bottom:0px } #pg-828-0 { margin-left:-15px;margin-right:-15px } #pg-828-0 .panel-grid-cell { padding-left:15px;padding-right:15px } @media (max-width:780px){ #pg-828-0 .panel-grid-cell { float:none;width:auto } #pl-828 .panel-grid , #pl-828 .panel-grid-cell {  } #pl-828 .panel-grid .panel-grid-cell-empty { display:none } #pl-828 .panel-grid .panel-grid-cell-mobile-last { margin-bottom:0px }  } <\/style><div class=\"panel-grid\" id=\"pg-828-0\" ><div class=\"panel-grid-cell\" id=\"pgc-828-0-0\" ><div class=\"so-panel widget widget_sow-editor panel-first-child\" id=\"panel-828-0-0-0\" data-index=\"0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>A multicentre prospective, interventional, randomised trial of PREOPerative radiosurgery compared with postoperative stereotactic radiotherapy for resectable brain metastases (PREOP-2)<\/strong><\/h2>\n<hr \/>\n<p><strong>Main Study PI (Switzerland)<\/strong><br \/>\nDr. Dr. Susanne Rogers<br \/>\nKantonsspital Aarau, Aarau, Switzerland<br \/>\n<a href=\"mailto:susanne.rogers@ksa.ch\">susanne.rogers@ksa.ch<\/a><\/p>\n<p><strong>Study PI (Germany)<\/strong><br \/>\nProf. Dr. med. Michael Synowitz<br \/>\nUniversity Medical Center Schleswig-Holstein, Campus Kiel<br \/>\n<a href=\"mailto:Michael.Synowitz@uksh.de\">Michael.Synowitz@uksh.de<\/a><\/p>\n<p><strong>Study design:<\/strong><br \/>\n\u25cf Multi-center, international, randomized, prospective, interventional 2-arm phase III study<\/p>\n<p><strong>Inclusion criteria:<\/strong><br \/>\n\u25cf Confirmed cancer diagnosis Brain metastasis &lt; 3 other brain metastases for single or multiple fraction radiosurgery No contraindication for MRI<\/p>\n<p><strong>Sample size:<\/strong><br \/>\n\u25cf160 patients needed, target 200 due to competing risks<\/p>\n<p><strong>Endpoints:<\/strong><br \/>\n\u25cf Primary endpoint: Incidence of leptomeningeal relapse at 12 months<br \/>\n\u25cf Secondary endpoint: Overall survival, neurological death, local control, quality of life<br \/>\n\u25cf Exploratory endpoints: Time to radiosurgery, time to neurosurgery, possible biomarker study<\/p>\n<p><strong>Trial registration<\/strong><\/p>\n<p>NCT05124236 <a href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT05124236\">https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT05124236<\/a><\/p>\n<\/div>\n<\/div><\/div><div class=\"so-panel widget widget_sow-image\" id=\"panel-828-0-0-1\" data-index=\"1\"><div class=\"so-widget-sow-image so-widget-sow-image-default-3f547a15eaaa\">\n\t<h3 class=\"widget-title\">Flowchart<\/h3>\n<div class=\"sow-image-container\">\n\t<img src=\"https:\/\/www.degro.org\/ag-stereotaxie\/wp-content\/uploads\/sites\/10\/2022\/08\/Flowshart-PREOP2.png\" width=\"605\" height=\"480\" srcset=\"https:\/\/www.degro.org\/ag-stereotaxie\/wp-content\/uploads\/sites\/10\/2022\/08\/Flowshart-PREOP2.png 605w, https:\/\/www.degro.org\/ag-stereotaxie\/wp-content\/uploads\/sites\/10\/2022\/08\/Flowshart-PREOP2-300x238.png 300w\" title=\"Flowchart\"  class=\"so-widget-image\"\/>\n<\/div>\n\n<\/div><\/div><div class=\"so-panel widget widget_sow-editor panel-last-child\" id=\"panel-828-0-0-2\" data-index=\"2\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong>Referenzen<\/strong><\/p>\n<p>Rogers S, Baumert B, Black O, et al. Stereotactic radiosurgery and radiotherapy for resected brain metastases: current pattern of care in the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Association for Radiation Oncology (DEGRO). Strahlenther Onkol. 2022; 198(10):919-925. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36006436\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36006436\/<\/a><\/p>\n<p>Rogers S, Schwyzer L, Lomax N. Preoperative radiosurgery of brain metastases (PREOP-1): A feasibility trial. Clin Transl Radiat Oncol. 2024; 47: 100798.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38938931\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38938931\/<\/a>\u00a0<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>#pg-828-0 .panel-grid-cell { float:none } #pl-828 .panel-grid-cell .so-panel { margin-bottom:30px } #pl-828 .panel-grid-cell .so-panel:last-child { margin-bottom:0px } #pg-828-0 { margin-left:-15px;margin-right:-15px } #pg-828-0 .panel-grid-cell { padding-left:15px;padding-right:15px } @media (max-width:780px){ #pg-828-0 .panel-grid-cell { float:none;width:auto } #pl-828 .panel-grid , #pl-828 .panel-grid-cell {  <\/p>\n","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/pages\/828"}],"collection":[{"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/comments?post=828"}],"version-history":[{"count":8,"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/pages\/828\/revisions"}],"predecessor-version":[{"id":1005,"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/pages\/828\/revisions\/1005"}],"wp:attachment":[{"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/media?parent=828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}