{"id":65,"date":"2017-06-29T11:44:31","date_gmt":"2017-06-29T09:44:31","guid":{"rendered":"https:\/\/www.degro.org\/ag-stereotaxie\/?page_id=65"},"modified":"2025-05-27T14:17:16","modified_gmt":"2025-05-27T12:17:16","slug":"randomized-phase-ii-trial-of-sbrt-for-painful-vertebral-metastases-dosis","status":"publish","type":"page","link":"https:\/\/www.degro.org\/ag-stereotaxie\/projekte\/aktuelle-projekte\/randomized-phase-ii-trial-of-sbrt-for-painful-vertebral-metastases-dosis\/","title":{"rendered":"DOSIS Trial"},"content":{"rendered":"<div id=\"pl-65\"><style scoped>#pg-65-0 .panel-grid-cell { float:none } #pl-65 .panel-grid-cell .so-panel { margin-bottom:30px } #pl-65 .panel-grid-cell .so-panel:last-child { margin-bottom:0px } #pg-65-0 { margin-left:-15px;margin-right:-15px } #pg-65-0 .panel-grid-cell { padding-left:15px;padding-right:15px } #panel-65-0-0-0 a { color:#009cd8 } @media (max-width:780px){ #pg-65-0 .panel-grid-cell { float:none;width:auto } #pl-65 .panel-grid , #pl-65 .panel-grid-cell {  } #pl-65 .panel-grid .panel-grid-cell-empty { display:none } #pl-65 .panel-grid .panel-grid-cell-mobile-last { margin-bottom:0px }  } <\/style><div class=\"panel-grid\" id=\"pg-65-0\" ><div class=\"panel-grid-cell\" id=\"pgc-65-0-0\" ><div class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" id=\"panel-65-0-0-0\" data-index=\"0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Dose-intensified Image-guided Fractionated Stereotactic Body Radiation Therapy for Painful Spinal Metastases (DOSIS) versus Conventional Radiation Therapy: a Phase II Randomised Controlled Trial<\/strong><\/h2>\n<hr \/>\n<h4 class=\"accordion-item open\"><span id=\"DeltaPlaceHolderMain\"><strong>Sponsor-Investigator:<\/strong><br \/>\n<\/span><span id=\"DeltaPlaceHolderMain\"><\/span><\/h4>\n<p class=\"accordion-item open\"><span id=\"DeltaPlaceHolderMain\">Prof. Dr. Matthias Guckenberger<br \/>\nUniversity Hospital Zurich<br \/>\n<a href=\"mailto:Matthias.Guckenberger@usz.ch\">Matthias.Guckenberger@usz.ch<\/a><\/span><\/p>\n<h4 class=\"accordion-item open\"><span id=\"DeltaPlaceHolderMain\"><strong>Study design: <\/strong><\/span><\/h4>\n<p class=\"accordion-item open\"><span id=\"DeltaPlaceHolderMain\">\u25cf Phase II, international, multicenter, randomized, open-label, prospective, controlled study<\/span><\/p>\n<h4><span id=\"DeltaPlaceHolderMain\"><strong>Study objective:<\/strong><\/span><\/h4>\n<p><span id=\"DeltaPlaceHolderMain\">\u25cf To compare long-term pain control after dose-intensified image-guided hypofractionated SBRT employing SIB versus conventional radiation therapy for painful mass-type spinal metastases.<\/span><\/p>\n<h4><span id=\"DeltaPlaceHolderMain\"><strong>Project status:<\/strong><\/span><\/h4>\n<ul>\n<li><span id=\"DeltaPlaceHolderMain\"><\/span><span id=\"DeltaPlaceHolderMain\">\u00a0Study closed (219 patients recruited)<\/span><\/li>\n<li><span id=\"DeltaPlaceHolderMain\">Follow-up ongoing<\/span><\/li>\n<\/ul>\n<h4><span id=\"DeltaPlaceHolderMain\">Major findings and results: <\/span><\/h4>\n<p><span id=\"DeltaPlaceHolderMain\">Matthias Guckenberger, Maria Hawkins, Michael Flentje, Reinhart A Sweeney<br \/>\n<strong>Fractionated radiosurgery for painful spinal metastases: DOSIS - a phase II trial.<\/strong><br \/>\nBMC Cancer 2012 Nov 19;12:530. doi: 10.1186\/1471-2407-12-530. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23164174\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23164174<\/a><\/span><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>#pg-65-0 .panel-grid-cell { float:none } #pl-65 .panel-grid-cell .so-panel { margin-bottom:30px } #pl-65 .panel-grid-cell .so-panel:last-child { margin-bottom:0px } #pg-65-0 { margin-left:-15px;margin-right:-15px } #pg-65-0 .panel-grid-cell { padding-left:15px;padding-right:15px } #panel-65-0-0-0 a { color:#009cd8 } @media (max-width:780px){ #pg-65-0 .panel-grid-cell { float:none;width:auto } #pl-65 .panel-grid <\/p>\n","protected":false},"author":8,"featured_media":0,"parent":77,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/pages\/65"}],"collection":[{"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/comments?post=65"}],"version-history":[{"count":6,"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/pages\/65\/revisions"}],"predecessor-version":[{"id":1061,"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/pages\/65\/revisions\/1061"}],"up":[{"embeddable":true,"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/pages\/77"}],"wp:attachment":[{"href":"https:\/\/www.degro.org\/ag-stereotaxie\/wp-json\/wp\/v2\/media?parent=65"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}